Indomethacin as a tocolytic harmful to preterm infant
نویسندگان
چکیده
منابع مشابه
Tocolytic Drugs for Women in Preterm Labour
Preterm birth is the most important single determinant of adverse infant outcome, in terms of both survival and quality of life. Although preterm birth is defined as being before 37 completed weeks, most mortality and morbidity is experienced by babies born before 34 weeks. Prevention and treatment of preterm labour is important, not as an end in itself, but as a means of reducing adverse event...
متن کاملTocolytic therapy for acute preterm labor.
The pathophysiology leading to preterm labor is not well understood and often multifactorial; initiating factors include intrauterine infection, inflammation, ischemia, overdistension, and hemorrhage. Given these different potential causes, directing therapy for preterm labor has been difficult and suboptimal. To date, no single drug has been identified as successful in treating all of the unde...
متن کاملEarly administration of indomethacin to preterm infants.
Indomethacin (0.2 mg/kg) or saline was given intravenously during the first 24 hours to 50 preterm infants in a double blind controlled trial. Eight of the control group later required treatment with indomethacin for clinical signs of left to right shunt, but only one in the treatment group (p = 0.03). Treatment with indomethacin prolonged bleeding time, raised serum creatinine concentrations, ...
متن کاملPreterm placental abruption: Tocolytic therapy regarded as a poor neonatal prognostic factor
Aim: To elucidate factors associated with a poor neonatal prognosis in preterm placental abruption. Methods: A multicenter retrospective study was conducted. A total of 247 cases with preterm placental abruption during 2009, derived from an electronic database constructed by the Japan Society of Obstetrics and Gynecology, were investigated as the subjects of this study, and were divided into th...
متن کاملSide-effect and vital sign profile of nifedipine as a tocolytic for preterm labour.
OBJECTIVE To examine the side-effect and vital sign profile of nifedipine used as a tocolytic. DESIGN Retrospective audit. SETTING Tertiary care university hospital, Hong Kong. PATIENTS Women presenting with preterm labour (before 34 weeks of gestation) between March 2001 and September 2004. MAIN OUTCOME MEASURES Maternal heart rate, blood pressure, and foetal heart rate were monitored ...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2015
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2015.08.022